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Karaya gum


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Other names/abbreviations: Kadaya gum
India gum
Indian tragacanth
Sterculia gum
Crystal gum
Kullo gum
 Katilo gum
Kuteera
Mucara
Siltex gum
Tab gum



Material type: Polymer
Material group: Hetero polysaccharide, branched
Monomer(s): D-galactose
D-galacturonic acid
L-rhamnose
Origin of the polymer: Natural
CAS-Number: 9000-36-6



Structure

L-rhamnose, D-galactose, D-galacturonic acid (ratio 4:6:5) [1].


Chemical properties

Acidic. Absorbs water to form viscous colloidal sols. A dispersion of gum karaya has a buffercapacity with pH 4.5-4.7 [1].


Biological properties

Antiviral activity:
Inhibitor/Concentration (μg/mL) 200
Adsorption HSV-1 in Vero cells [2] 85
Adsorption HSV-2 in Vero cells [2] 100
Adsorption and replication HSV-1 in Vero cells [2] 85
Adsorption and replication HSV-2 in Vero cells [2] 80
Inhibition of virus multiplication in cells.


Cell line Concentration
Vero cells [2] 200
Maximal non-cytotoxic concentration (μg/ml).


Molecular biology
100% inhibition on the restriction enzyme HindIII at 100 μg polysaccharide / μg λ DNA [3].


Misc.
No enhancement of lectin hemagglutinability [4].


Physical properties

Appearance

Physical state @ 20°C: Solid
Color: Light brown


Bulk properties

Molecular weight (g/mol): 9,500,000 (Approximately) [1]




Occurence, isolation & synthesis

Occurence
Sterculia urens [1].


References

1: Glicksman,M. Gum Technology in the Food Industry
(1969) Academic Press

2: Marchetti,M., Pisani,S., Pietropaolo,V., Seganti,L., Nicoletti,R., Orsi,N. Inhibition of Herpes Simplex Virus Infection by Negatively Charged and Neutral Carbohydrate Polymers
J. Chemother. (1995) 7 90-96

3: Do,N., Adams,R.P. A simple technique for removing plant polysaccharide contaminants from DNA
Biotechniques (1991) 10 162-166

4: Melito,C.A.U., Levy-Benshimol,A. Vegetable gums modify lectin hemagglutinability
Acta Cient. Venez. (1992) 43 312-314







© Michael Pilgaard
Created: March 10, 2008